{"id":3797,"date":"2024-06-18T14:12:45","date_gmt":"2024-06-18T12:12:45","guid":{"rendered":"https:\/\/ifevet.com\/uk\/?p=3797"},"modified":"2025-01-09T09:16:06","modified_gmt":"2025-01-09T09:16:06","slug":"systemic-ischaemia-reperfusion-syndrome","status":"publish","type":"post","link":"https:\/\/ifevet.com\/uk\/systemic-ischaemia-reperfusion-syndrome\/","title":{"rendered":"Systemic Ischaemia-Reperfusion Syndrome"},"content":{"rendered":"

Definition<\/strong>: Sepsis-like clinical presentation as patients present with systemic inflammation (SIRS), coagulation activation (DIC) and endothelial disruption.<\/p>\n

Clinical signs:<\/strong><\/p>\n

    \n
  1. tachycardia\/bradycardia<\/li>\n
  2. tachypnoea<\/li>\n
  3. fever\/hypothermia<\/li>\n
  4. hypoperfusion<\/li>\n
  5. multi-organ failure<\/li>\n
  6. bleeding, oedema, etc.<\/li>\n<\/ol>\n

    Treatment:<\/strong><\/p>\n

      \n
    1. Haemodynamic optimisation: use of early goal-directed therapy. Our goals will be a central venous pressure of 0-10 cm H2O, MAP 80-120 mmHg, ScvO2 > 70% and lactate < 2.5 mmol\/L.<\/li>\n
    2. Glycaemic control: Hyperglycaemia worsens ischaemic brain damage. Regular insulin is recommended to keep glucose below 180 mg\/dL.<\/li>\n
    3. Adrenal dysfunction: Critical illness-related corticosteroid insufficiency (CIRCI) has been described in people after PCP. Consider low dose hydrocortisone\/methylprednisolone in patients who are vasopressor dependent.<\/li>\n<\/ol>\n

      \"\"<\/p>\n","protected":false},"excerpt":{"rendered":"

      Definition: Sepsis-like clinical presentation as patients present with systemic inflammation (SIRS), coagulation activation (DIC) and endothelial disruption. Clinical signs: tachycardia\/bradycardia tachypnoea fever\/hypothermia hypoperfusion multi-organ failure bleeding, oedema, etc. Treatment: Haemodynamic optimisation: use of early goal-directed therapy. Our goals will be a central venous pressure of 0-10 cm H2O, MAP 80-120 mmHg, ScvO2 > 70% and […]<\/p>\n","protected":false},"author":210,"featured_media":3798,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-3797","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-clinical-content"],"yoast_head":"\nSystemic Ischaemia-Reperfusion Syndrome - Ifevet International - UK<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/ifevet.com\/uk\/systemic-ischaemia-reperfusion-syndrome\/\" \/>\n<meta property=\"og:locale\" content=\"es_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Systemic Ischaemia-Reperfusion Syndrome - Ifevet International - UK\" \/>\n<meta property=\"og:description\" content=\"Definition: Sepsis-like clinical presentation as patients present with systemic inflammation (SIRS), coagulation activation (DIC) and endothelial disruption. Clinical signs: tachycardia\/bradycardia tachypnoea fever\/hypothermia hypoperfusion multi-organ failure bleeding, oedema, etc. Treatment: Haemodynamic optimisation: use of early goal-directed therapy. Our goals will be a central venous pressure of 0-10 cm H2O, MAP 80-120 mmHg, ScvO2 > 70% and […]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/ifevet.com\/uk\/systemic-ischaemia-reperfusion-syndrome\/\" \/>\n<meta property=\"og:site_name\" content=\"Ifevet International - UK\" \/>\n<meta property=\"article:published_time\" content=\"2024-06-18T12:12:45+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-09T09:16:06+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/ifevet.com\/uk\/wp-content\/uploads\/sites\/16\/2024\/06\/sindrome-isquemia-reperfusion-sistemica.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"1000\" \/>\n\t<meta property=\"og:image:height\" content=\"667\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"anamartinez\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Escrito por\" \/>\n\t<meta name=\"twitter:data1\" content=\"anamartinez\" \/>\n\t<meta name=\"twitter:label2\" content=\"Tiempo de lectura\" \/>\n\t<meta name=\"twitter:data2\" content=\"1 minuto\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/ifevet.com\\\/uk\\\/systemic-ischaemia-reperfusion-syndrome\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/ifevet.com\\\/uk\\\/systemic-ischaemia-reperfusion-syndrome\\\/\"},\"author\":{\"name\":\"anamartinez\",\"@id\":\"https:\\\/\\\/ifevet.com\\\/uk\\\/#\\\/schema\\\/person\\\/2c7407e9b850c9180badf5f1340fd579\"},\"headline\":\"Systemic Ischaemia-Reperfusion Syndrome\",\"datePublished\":\"2024-06-18T12:12:45+00:00\",\"dateModified\":\"2025-01-09T09:16:06+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/ifevet.com\\\/uk\\\/systemic-ischaemia-reperfusion-syndrome\\\/\"},\"wordCount\":106,\"commentCount\":0,\"image\":{\"@id\":\"https:\\\/\\\/ifevet.com\\\/uk\\\/systemic-ischaemia-reperfusion-syndrome\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/ifevet.com\\\/uk\\\/wp-content\\\/uploads\\\/sites\\\/16\\\/2024\\\/06\\\/sindrome-isquemia-reperfusion-sistemica.webp\",\"articleSection\":[\"Clinical content\"],\"inLanguage\":\"es\",\"potentialAction\":[{\"@type\":\"CommentAction\",\"name\":\"Comment\",\"target\":[\"https:\\\/\\\/ifevet.com\\\/uk\\\/systemic-ischaemia-reperfusion-syndrome\\\/#respond\"]}]},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/ifevet.com\\\/uk\\\/systemic-ischaemia-reperfusion-syndrome\\\/\",\"url\":\"https:\\\/\\\/ifevet.com\\\/uk\\\/systemic-ischaemia-reperfusion-syndrome\\\/\",\"name\":\"Systemic Ischaemia-Reperfusion Syndrome - 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